(DOWNLOAD) "Asymmetric Synthesis of Aminophosphonic Acids Mediated by Chiral Sulfinyl Auxiliary: Recent Advances (Report)" by Piotr Lyzwa & Marian Mikolajczyk # eBook PDF Kindle ePub Free
eBook details
- Title: Asymmetric Synthesis of Aminophosphonic Acids Mediated by Chiral Sulfinyl Auxiliary: Recent Advances (Report)
- Author : Piotr Lyzwa & Marian Mikolajczyk
- Release Date : January 01, 2010
- Genre: Chemistry,Books,Science & Nature,Professional & Technical,Engineering,
- Pages : * pages
- Size : 71 KB
Description
INTRODUCTION Aminophosphonic acids 1 are phosphorus analogs of amino acids in which the planar carboxylic group is replaced by a tetrahedral phosphonic acid moiety. Because of the tetrahedral configuration at phosphorus, aminophosphonic acids mimic the unstable tetrahedral carbon intermediates formed in enzyme-mediated peptide bond cleavage and act as enzyme inhibitors. They selectively inhibit peptidases and proteinases (e.g., HIV protease, serine protease). Many natural and synthetic aminophosphonic acids and their conjugates with peptides exhibit antibacterial, anticancer, and antiviral properties. Some of them show pesticidal, insecticidal, and herbicidal activity. As such, a few of them have found commercial applications in medicine and agriculture [1,2].